for the lazy people: Wikipedia - GBU-57A/B MOP

Hey, he at least has experience with grocery shoppers, which can be awful people to deal with, just like terrorists!

They already have issues finding partners, because no shit, i don’t want a bigot or nazi as a partner too. So they is already a natural selection pressure on them which reduces their numbers significantly over the next few generations, if we keep it up!

Nope, 0 / 3 = 0 -> 0 + 4 = 4°C

Division/Multiplication always goes before Addition/Subtraction.

Yep, when i saw that the Blackout had no effect i came over here and never looked back.

I use Lemmy and Mastodon (and sometimes Pixelfed), but have currently a Bluesky-phase. I also noticed a lot of anxiety when using bluesky regarding current events, so i’m thinking of dropping it again, i can cope better with lemmy, much less hectic.

Mortal Sin, a Melee - Roguellike with great visuals and a dev that cares a lot.

ΔV: Rings of Saturn, a hard-scifi 2d asteroid mining game. Great to relax to, a nice community and a great dev, linux native!

Deadlink, a Roguelike arena shooter, tight controls, pretty hard for an aging man like me, but i still like it, even if it puts me in my place regularly lol

No, they are the factories of the cell, building proteins. :-)

Just to set this in relation, the transatlantic roundtrips of those jets are the equivalent to 540000000 questions to deepseek r1, or 1710000000 questions to quen 2.5. for quen, that means to ask about 36 questions per minute.

for the next 90 years.

The book was pretty good, at least when i read it as a teenager. Don’t know if i’d like it now

from what i remember (it’s been a few years since i studied this stuff lol) you can only arrest the cell cycle (dismantling -> duplication of chromosomes -> separation of chromosomes -> completion of division) at specific points, and can’t go in reverse. Theres a whole cascade of signals, that when started, are running their way to specific checkpoints. if a cell is stuck for too long at any checkpoint, it commits suicide, because that’s THE sign for unrecoverable DNA damage. And if a cell starts ignoring checkpoints and suicide signals, it’s called cancer.

Many antibiotics work that way btw - they look a lot like nucleotides (A C G T), but if a bacterium adds them when copying instead of one of the “letters”, the machinery gets stuck, and the bacterium cant divide anymore. That gives the immune system time to kill them off. Bacteria replicate a lot and have no proofreading of what they are copying, so they are susceptible to this. Animal cells have proofreading AND the ability to correct an error, so we are fine.

I loved studying this stuff. i did NOT love the crapload of chemistry i had to learn, but even that was highly interesting.

You are right (at the 8 cell stage you can still separate them and treat them one at a time, giving you multiple shots at IVF)

Two of the main issues regarding gene editing when not talking single cells are the transfer into the nucleus, and then accessing the DNA you want.

In bacteria, the DNA kinda just swims around in the cell, which makes editing easy if you can get the CRISPR/Cas9 complex in the cell. But animal cells have another membrane surrounding the DNA, making the transfer less than straightforward.

Regarding access: our DNA isn’t lying around like mom’s spaghetti, but rather pretty tightly packed around histones - a protein octamer.

This means that your target might not be reachable (the cell itself has 3 options iirc: slide the DNA over the surface of the histone, replace a part of the histone with an alternative, or remove the histone altogether) Since the way the DNA is wound around the histones affects gene activity (something tightly packed is not active, something in a loose area is getting transcribed into mRNA and therefore possibly active), you cannot just unwind all of it.

The only time this is not the case is during cell division, where the nucleus is getting dismantled so the DNA can be duplicated and both new cells can get their own copy. But many cells do not divide in an adult (except for a reservoir of stem cells which are there to replace lost cells)

So, it’s all very complicated.

I’m no fan of AI “answers”, because if i search for something, i’d like to have access to the source or at least know if i depend on a random social media post as my answer. I’m also pretty sure that - if they are smart, and they (mostly) are - caching of questions and answers will cut down on the amount of total questions asked.

and then there are things like grok, which fuck with air quality because elon couldn’t wait until the power grid was usable at his datacenter (or open a datacenter where you have access to the required amount of power) and uses dozens of gas turbines for power (without permits, because when the penalty is a fine, it’s just the cost of doing business)

https://www.desmog.com/2025/06/13/xai-data-centre-emits-plumes-of-pollution-new-video-shows/

Because if there is something that can be done in a responsible way, you can count on elon to do it in the most braindead way possible.

e: direct link to the video: https://www.youtube.com/watch?v=mSWgDOzfKRI

The “Test” will probably be in line with a psych eval like we already have for our military, which will be enough for cases like this, because he was unfit to serve.

he was still able to get a gun licence, because in austria you are only blocked from getting a gun licence (for 15 years IIRC) if you refuse to serve in the military on ethical grounds and do civil service instead, and the data from the military evaluation is kept secret because of privacy laws.

That would take a majority vote, not only a single party change. Our system here in austria isn’t perfect (like most of the world), but it is not the broken mess the US have.

Regardless, i’d say the move to stronger regulation is welcome here. The shooter had his guns legally, even tho he was deemed unfit for military service, which screams “regulatory hole to fix ASAP”

looks like there is broad support for making sure that whoever wants a gun to be stable enough to handle them without shooting up a school.

They are safe for car passengers, and a nightmare for everyone else on the street. High hoods with bad sight for drivers and awful impact profile for pedestrians, heavy cars which make low speed collisions much more deadly for everyone not protected by 3 tons of steel. Safety should be for everyone, not only car passengers.

just to set the record straight:

“For example, having DeepSeek R1 (70 billion parameters) answer 600,000 questions would create CO2 emissions equal to a round-trip flight from London to New York. Meanwhile, Qwen 2.5 (72 billion parameters) can answer more than three times as many questions (about 1.9 million) with similar accuracy rates while generating the same emissions.”

i’d say that makes the average usage for personal reasons an non-issue.

Generally, heating and cooling are the main energy consumption for domestic purposes. next up is the car, and then electrical consumption. (from what i remember).

as long as you don’t take a transatlantic trip your fine:

“For example, having DeepSeek R1 (70 billion parameters) answer 600,000 questions would create CO2 emissions equal to a round-trip flight from London to New York. Meanwhile, Qwen 2.5 (72 billion parameters) can answer more than three times as many questions (about 1.9 million) with similar accuracy rates while generating the same emissions.”

i don’t know y’all, but i can say it takes me a long-ass time to ask that many questions.

GenX here, my father was a racist and ran with a similar racist crowd, and i was disgusted pretty soon after i started to comprehend the shit they spew.

That crap they said sometimes still comes into my mind when seeing non-whites (i heard that stuff a lot, as my father descended into his alcoholism over 2 decades), and then i firmly disagree with those thoughts and feel icky. Racism (and i believe it’s the same for sexism) is an active choice, even when growing up in a racist environment.

And for Linux: Krusader

https://krusader.org/